Glucocorticoids, epigenetic control and stress resilience
نویسندگان
چکیده
منابع مشابه
Glucocorticoids, epigenetic control and stress resilience
Glucocorticoid hormones play a pivotal role in the response to stressful challenges. The surge in glucocorticoid hormone secretion after stress needs to be tightly controlled with characteristics like peak height, curvature and duration depending on the nature and severity of the challenge. This is important as chronic hyper- or hypo-responses are detrimental to health due to increasing the ris...
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There is emerging evidence that individuals have the capacity to learn to be resilient by developing protective mechanisms that prevent them from the maladaptive effects of stress that can contribute to addiction. The emerging field of the neuroscience of resilience is beginning to uncover the circuits and molecules that protect against stress-related neuropsychiatric diseases, such as addictio...
متن کاملStress , Glucocorticoids , and the Brain
• Corticosteroids function to optimize the stress response and are thus essential for the organism to cope with the stressor. • Corticosteroid signaling is mediated by two receptors: the high-affinity mineralocorticoid receptor and the low-affinity glucocorticoid receptor. • Imbalance between central glucocorticoid and mineralocorticoid receptor affects the secretion of corticosteroids and has ...
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Making memories of a stressful life event is essential for an organism's survival as it allows it to adapt and respond in a more appropriate manner should the situation occur again. However, it may be envisaged that extremely stressful events can lead to formation of traumatic memories that are detrimental to the organism and lead to psychiatric disorders such as post-traumatic stress disorder ...
متن کاملSymposium 11: Stress, Glucocorticoids and Memory
The hippocampal formation is of crucial importance for cognitive processes and alterations in this brain area are associated with a selective impairment of memory performance. Increasing evidence suggests a connection between structural alterations and volumetric reduction of the hippocampal formation, cognitive impairments and disturbances of the activity of the hypothalamo-pituitary-adrenal (...
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ژورنال
عنوان ژورنال: Neurobiology of Stress
سال: 2015
ISSN: 2352-2895
DOI: 10.1016/j.ynstr.2014.10.001